CEACAM6 and neoplasm: pHLIPs spontaneously fold to form α helices, which insert and cross the cell membrane to transport conjugated NADs into cells.191,411 In anti-tumor therapy, it has been demonstrated that pHLIPs can deliver PNAs to cancer cells due to their natural targeting abilities.412,413 For example, in a mouse model of lung adenocarcinoma, the delivery of PNAs targeting CEACAM6 using pHLIPs resulted in CEACAM6 gene silencing and tumor growth inhibition.414