KDR and neoplasm: With technological advances, various novel POCs have demonstrated the feasibility of delivering siRNA, ASO, and miRNA in vitro.406,476 Studies have found that bivalent cRGD successfully transports VEGF receptor 2 (VEGFR2)-siRNA into tumor cells in a mouse non-small cell lung cancer xenograft model, downregulating VEGFR2 expression and significantly inhibiting cancer progression.406 Kim et al.402 designed a dual-targeting drug delivery system for miR-21 inhibitors, consisting of a PDL1-binding peptide covalently linked with an anti-miR-21 inhibitor via a click reaction.