PLK1 and cancer: Their flexible surfaces enable nucleic acids to bind to the gold nanoparticles directly.367,368 For example, Shrestha et al.369 developed a gold nanoparticle-mediated drug delivery platform for the co-delivery of doxorubicin and polo-like kinase 1 (Plk1) siRNA, offering an adaptable and straightforward platform for studying drug-siRNA combinations in cancer treatment.