PPARGC1A and hepatocellular carcinoma: Studies have shown that BAF60a is involved in the accumulation of cell lipid droplets and palmitic acid-induced cell senescence, in hepatoma cells HepG2, BAF60a (SMARCD1) is associated with PGC-1α activity and its transcriptional activation ability, FAO gene expression, when BAF60a (SMARCD1) is silenced, the expression of PGC-1α and FAO is down-regulated, and the lipid droplets of hepatocytes are significantly accumulated, on the contrary, when BAF60a is overexpressed, the expression of PGC-1α and FAO is up-regulated.