POU2AF2 and POU2AF3 binding was assessed independently, as contributing studies indicate the expression and dependence of SCLC-P cell-line survival on these genes to be mutually exclusive.9 16 Occupancy of both POU2AF2 and POU2AF3 was detected at up to 17 distinct regions near 19 of the 21 refined trans-eQTL target loci (q<0.05). Here, POU2AF2 is linked to small cell lung carcinoma.