As all three 11q23.1 cis-eQTL targets are poorly expressed across CRC cell lines and highly correlated in human bulk expression, we sought to delineate the dependence of tuft cell abundance and trans-eQTL target expression on POU2AF2 and POU2AF3 in the colon by genetic perturbation of these genes in mouse models. Here, POU2AF3 is linked to colorectal carcinoma.