GP surgery consultations for COPD were 2.7% less frequent (58.6% vs 61.3%), with slightly fewer visits per patient (2.18 in CRP-guided group compared with 2.27 in usual-care group) resulting in an overall non-significant difference in primary care cost due to COPD in the CRP-guided group of −£6.35 (95% CI −£18.91 to £6.11, p=0.627) per patient. This evidence concerns the gene CRP and chronic obstructive pulmonary disease.