Additionally, alterations in the expression of key proteins associated with the PI3K/AKT/mTOR and EMT pathways, including p-PI3K, p-AKT, p-mTOR, E-cadherin, N-cadherin, and Slug, further substantiate the regulatory role of HSPB6 in modulating tumor dynamics. The gene discussed is SNAI2; the disease is neoplasm.