To dig deeper into the role of YAP1 in the pathogenesis of DKD, we generated mice with renal tubule cell-specific Yap1 knockout mice (TKO, KspCre/Yap1flox/flox), with their littermates lacking the KspCre allele serving as control mice (CTL, WT/Yap1flox/flox). The gene discussed is YAP1; the disease is diabetic kidney disease.