Moreover, immunohistochemistry of tubulointerstitial compartment of kidney sections confirmed a reduction of YAP1 protein and an increase in S127 phosphorylated YAP1 from patients of biopsy-approved DKD, particularly in the late-stage DKD subjects (Fig. 2D–F), suggesting augmented YAP1 protein degradation in diabetic tubule cells. Here, YAP1 is linked to diabetic kidney disease.