In the case of the central HCV protein, it acts as a ligand for TLR2 in human kupffer cells, inducing the production of cytokines such as IL-10, and the blockade of TLR2 by the pathophysiology of HBV or HCV, being able inhibit the production of IL-10, overexpressed levels of this cytokine are also common in the pathogenesis of infection.42 The gene discussed is IL10; the disease is infection.