In the microenvironment of hepatocarcinogenesis of infection, liver damage can occur producing IL-8/CXCL-8, which increases the expression of apoptosis, with IL-10 produced by Th2 cells, inhibiting the function of monocytes, macrophages, T-cells, preventing the production of IL-1, IL-6, IL-8, IL-12 and TNF-α in HBV and HCV co-infection.79 The gene discussed is TNF; the disease is coinfection.