CTA are known to be expressed in HNSCC and often members of the MAGE family as well as the New York Esophageal squamous cell carcinoma 1 antigen (NY-ESO-1) are detected.[9] Yet, in HPV-negative HNSCC, the expression of MAGEA family antigens, and NY-ESO-1[9,10] as well as antibodies against MAGEA1 and MAGEA4 has been associated with shorter OS.[11] Demethylation of CTAs serving as tumor associated antigens might be an opportunity to increase anti-tumor T cell responses. Here, MAGEA4 is linked to head and neck squamous cell carcinoma.