In addition, nodifferences were present in D1 and D2 but in COMT in rats exposed to HFD; this differencewas located in obesity-prone (OP) rats.27 One part of the mesolimbic circuit is the nucleus accumbens (Nacb).The Nacb shell motivates consumption of dietary fat in rats, and whenD1Rs are inhibited in the lateral shell, a reduction in fat consumptioncan be seen.32 The endocannabinoid systemis formed by CB1 and CB2 receptors. Here, CNR1 is linked to obesity due to melanocortin 4 receptor deficiency.