CDKN2D and neoplasm: UTX-induced expression of tumor-suppressive programs, including genes associated with cell-cycle arrest and therapy-induced senescence, is necessary for the antileukemic effects of menin inhibitors, and loss of UTX function is implicated in menin inhibitor resistance.55 Upon menin inhibition, UTX directly upregulates the expression of Cdkn2c/Ink4c and Cdkn2d/Ink4d, which encode inhibitors of the CDKs—CDK4 and CDK6.