KMT2A and leukemia: They found that IKZF1 physically interacts with both menin and KMT2A at the transcription start sites (TSSs) of KMT2A-FP targets, and despite its function as a sequence-specific DNA-binding protein, it may direct the localization of menin-KMT2A-FP in a manner similar to LEDGF.18,30 Clearly, the interaction of KMT2A-FPs with menin is a critical mechanism of transformation and pathologic self-renewal in MLL-rearranged leukemias.