PRC1 and neoplasm: Inactivation of PRC1 is also implicated in menin inhibitor resistance, which similarly results in the inhibition of tumor-suppressive programs through the loss of H3K27 methylation, the loss of CDK inhibitor expression, and the overactivation of MYC.103,104 Therefore, there may be a rationale for combining menin inhibitors with EZH2/PRC2 or PRC1 inhibitors.