SQSTM1 and adenoma: In the liver, p62 sequesters the E3 ligase KEAP1 and stabilizes the antioxidant transcription factor NRF2/NFE2L2.15 The deletion of p62 or NRF2 abolishes liver damage and subsequent benign adenoma formation induced by ATG5 or ATG7 loss.15–17 The importance of autophagy to suppress liver damage has further been demonstrated by hepatic deletion of RB1CC1.18 In contrast, the physiological impact of inhibiting autophagosome biogenesis downstream of LC3 conjugation is not well understood.