VPS37A and hepatocellular carcinoma: The ESCRT-I subunit VPS37A, also known as hepatocellular carcinoma-related protein 1 (HCRP1), was originally discovered as a cell growth-regulatory protein frequently downregulated in hepatocellular carcinoma (HCC).23 We have recently demonstrated a unique role of VPS37A in directing the ESCRT machinery to the phagophores.7 The autophagy-specific function of VPS37A is exerted by its N-terminal ubiquitin E2 variant-like (UEVL) domain-containing region,24 which is absent in other VPS37 homologs.