Detailed statistical differences between groups were present on Fig. 8B. The discrepancies between the effects of the G721-0282 compound on CDH2 mRNA in U-87 MG and glioblastoma spheroids may suggest a regulatory function of CHI3L1 in N-cadherin and a direct compensation effect occurred in glioblastoma cells (Fig. 8B). The gene discussed is CHI3L1; the disease is glioblastoma.