Recent studies have revealed elevated levels of proteins associated with aging, such as cell cycle repressors (p16, p53, and p21), in various cell types, including astrocytes, microglia, and neurons in the brains of AD patients (Baker et al. 2018; Pekny et al. 2016; Turnquist et al. 2016; McShea et al. 1997). The gene discussed is TP53; the disease is Alzheimer disease.