Several studies have demonstrated the presence of various inflammatory markers in the brains of individuals with Alzheimer's disease, including elevated levels of inflammatory cytokines such as interleukin-1 beta (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α), as well as chemokines such as such as IL-8 (interleukin-8), along with the accumulation of activated microglia in the affected regions, particularly the hippocampus, cerebral cortex, amygdala, and basal forebrain, which are critical for memory and cognitive functions. The gene discussed is CXCL8; the disease is early-onset autosomal dominant Alzheimer disease.