Liberal transfusion, by setting a higher hemoglobin transfusion threshold (e.g., Hemoglobin (Hb) ≤ 10 g/dL), aims to maintain a sufficient Hb level to ensure adequate oxygen supply to the brain, potentially mitigating secondary brain injury due to anemia and improving neurological outcomes [21–23]. The gene discussed is GSTM1; the disease is anemia.