Finally, pituitary organoids derived from human embryonic stem cells have been transplanted subcutaneously into mice with hypopituitarism; grafted cells were able to secrete ACTH and respond to corticotropin-releasing hormone stimulation (Sasaki et al., 2023), paving the way for innovative substitutive treatments in patients with hypopituitarism (Taga et al., 2023). This evidence concerns the gene CRH and hypopituitarism.