A focus on older people was found in studies evaluating BBs (5/12), ACEIs (4/12), diuretics (4/11), ARBs (4/10), CCBs (2/7), centrally acting antihypertensives (1/6) and angiotensin receptor–neprilysin inhibitors (ARNIs) (1/5).[7, 19, 20, 52, 54, 70, 74, 76, 96, 99] Notably, 3/5 ARNI studies included patients with heart failure, while one cohort study of ACEIs and ARBs focused on patients with acute kidney injury.[33, 69, 99, 104]. Here, MME is linked to acute kidney injury.