At the same time, LOP 2 and LOP 3 cells had an increased expression of BMP-2 gene from seven days of 1,25(OH)2D3 treatment (mRNA=9.02; mRNA=11.71 respectively), which was significantly different compared to the CONTROL and OM groups (Figure 2B) (P<0.05). The gene discussed is BMP2; the disease is ocular melanoma.