However, thisstudy proved that the effect of PAA against renal fibrosis is only associated withPERK-eIF2α-ATF4-CHOP signaling pathway, which is consistent with the previouslyreported mechanism of renin in UUO mice (29).Additionally, Chen et al. (30) reported thatforsythiaside A can alleviate sepsis-induced acute kidney injury viaPERK-eIF2α-ATF4-CHOP pathway-mediated apoptosis and inflammation, which isconsistent with our results. Here, REN is linked to renal fibrosis.