In a Tunisian family with a high degree of consanguinity, an MCM8 gene variant that causes a deficiency in the repair of chromosomal breakage, which can cause ovarian failure, was detected.(7) In Saudi Arabia, the NG_042869.1:g.40270G>A variant was identified in three sisters with hypergonadotropic primary amenorrhea.(8) In 2015, full-exome sequencing identified two new homozygous mutations in MCM8, one at the splicing site (c.1954-1G>A) and the other at the frameshift site (c.1469-1470 insTA). The gene discussed is MCM8; the disease is Primary amenorrhea.