It is characterized by amenorrhea, infertility, hypoestrogenism, and elevated serum follicle-stimulating hormone (FSH) levels.(2) Although there is no diagnostic accuracy for POI, the Guideline Development Group of the World Health Organization recommends the following diagnostic criteria: oligo/amenorrhea for at least 4 months, associated with FSH values above 25 IU/L, measured on two occasions with an interval greater than 4 weeks. This evidence concerns the gene BRD2 and amenorrhea.