CRH and Atrophy: Rodent studies show that neonatal rats treated with dexamethasone show reduced GCR in response to cold and restraint stress later in life (Felszeghy et al., 2000), while mice subjected to prolonged low-dose corticosterone exposure show suppressed GCR, adrenal atrophy, and decreased CRH mRNA levels in the PVN (Kinlein et al., 2015).