In summary, the modification of retinal efemp1 in zebrafish resulted in reduced spatial visual sensitivity, axial myopia, eye enlargement, altered retinal function, myopia-associated gene expression changes (i.e. egr1, efemp1, tgfb1a, vegfab, rbp3), and redistribution of inner retinal EFEMP1, TIMP2 and MMP2 proteins, under normal rearing. This evidence concerns the gene EGR1 and myopia.