This resembles the age-related slowing of b-wave implicit time reported in some, but not all, human patients with Malattia Leventinese, a retinal dystrophy caused by a gain-of-function efemp1 mutation (c.1033C>T, p.Arg345Trp) (Gerber et al., 2003). The gene discussed is EFEMP1; the disease is inherited retinal dystrophy.