In summary, the modification of retinal efemp1 in zebrafish resulted in reduced spatial visual sensitivity, axial myopia, eye enlargement, altered retinal function, myopia-associated gene expression changes (i.e. egr1, efemp1, tgfb1a, vegfab, rbp3), and redistribution of inner retinal EFEMP1, TIMP2 and MMP2 proteins, under normal rearing. The gene discussed is TIMP2; the disease is myopia.