RUNX2 and osteoporosis: Furthermore, the collective data indicate that overexpression of certain miRNAs can inhibit the expression of downstream osteogenesis-related markers OCN, Col1, Runx2, ALP, and Osx by inhibiting key proteins, such as RhoA, ROCKII, CaMKII, and PKC in the non-classical Wnt/Ca2+ signaling pathway, thereby promoting the progression of osteoporosis.