RUNX2 and osteoporosis: In addition, clinical trials revealed that the overexpression of miR-203 enhanced the expression levels of the ALP, Bglap, and Runx2 bone-related genes in postmenopausal patients with osteoporosis and reduced the expression levels of peroxisome proliferator-activated receptor-gamma (PPARγ) and lipoprotein lipase (LPL) genes associated with fat production [96].