RUNX2 and osteoporosis: Gossypol also significantly enhanced medullary and cortical BMD, the expression of Wnt protein, β-catenin, and GSK-3β, as well as the mRNA levels of osteogenesis-related genes, including osteocalcin, Runx2, OPG, and COL1A1, in mice with osteoporosis compared to control mice [105].