We show that proteins encoded by RO60, LARP7, MOV10, ZCCHC3, MEPCE, YARS2, RPL18A, RP27A, H2BC17, but notCORO1B, DDX6, PABC1, and PABC4, are indeed targeted by autoantibodies in SLE patients in a manner that aligns with the presence of anti-ORF1p autoantibodies. Here, MEPCE is linked to systemic lupus erythematosus.