The sources of nucleic acids that trigger cGAS, MDA5, and RIG-I are unknown [8], but double-stranded RNA has been shown to trigger type I IFN production through Z-DNA binding protein-1 (ZBP1) [15], which recognizes both RNA and DNA in the Z-configuration, in Crohn’s disease [16] and in several autoinflammatory disease models [17]. This evidence concerns the gene ZBP1 and Crohn disease.