Obesity leads to the formation of apoptotic centers within hypertrophic adipocytes [9,53], leptin secretion, unfolded protein responses activated by ER stress [54], secretion of MCP-1 from hypoxia-activated macrophages, and lipolysis that releases free FAs, which ultimately lead to immune cell infiltration, inflammation, and insulin resistance [55]. This evidence concerns the gene CCL2 and Insulin resistance.