The IVW analysis indicated that ischemic stroke (OR = 1.29, 95% CI 1.04–1.60; p = 0.020), hypothyroidism (OR = 1.05, 95% CI 1.00–1.11; p = 0.048), high blood pressure (OR = 1.10, 95% CI 1.01–1.19; p = 0.028), high cholesterol (OR = 1.10, 95% CI 1.01–1.20; p = 0.024), HMGCR (OR = 1.19, 95% CI 1.06–1.33; p = 0.003), and beta-blocking agents (OR = 1.20, 95% CI 1.06–1.38; p = 0.006) are associated with an increased risk of epilepsy. The gene discussed is HMGCR; the disease is epilepsy.