This study indicated that compounds of lignan, β-carotene, β-sitosterol, hederagenin, berberine, and baicalein from LJF mainly regulated core targets of MAPK8, CTNNB1, NFKB1, EGFR, BCL2, and NFE2L2 that involved in AD progression. Here, MAPK8 is linked to Alzheimer disease.