TNF and coinfection: Mtb infection status differed by index case HIV co-infection status for the QFT-Plus IFN-γ endpoint (35.7% of PLWH vs 62.3% of persons without HIV with Mtb infection by a positive QFT-Plus, OR 0.17, CI 0.04–0.82, p=0.03), but not TNF or IL-2 endpoints (Table 5) Together, this data suggests that HIV co-infection may be associated with significantly lower odds of Mtb infection in HHC when the QFT-Plus IFN-γ endpoint is used alone.