Although we did not observe a difference in the lung burden of PAO1 WT or PAO1 ΔmexEFoprN infected mice that survived through day 7 (Fig. 4E), the mutant caused lethality of 50% infected mice by day 3 post infection, but no lethality was observed in PAO1 infected mice (Fig. 4F). Here, SMOX is linked to infection.