Here, we analyze histological patterns of TMEM106B in murine models of C9ORF72-related amyotrophic lateral sclerosis and frontotemporal dementia (C9-ALS/FTD), SOD1-related ALS, and tauopathy and compare these to postmortem human tissue from patients with C9-ALS/FTD, Alzheimer’s disease (AD), and AD with limbic-predominant age-related TDP-43 encephalopathy (AD/LATE). This evidence concerns the gene TMEM106B and tauopathy.