In addition, we found that the presence of neuronal TMEM106B puncta is rare in the occipital cortices for both healthy and C9 patients (Figure S2A, B), suggesting that the TMEM106B:TDP-43 correlation is specific to the affected brain region in C9-ALS and C9-ALS/FTD. This evidence concerns the gene TMEM106B and amyotrophic lateral sclerosis.