CD8A and neoplasm: Figures 3C&D show that the profile of epitopes presented by DC loaded with B16-F10-(AIRE) lysates raised T cell responses which could very effectively cross-react back onto the profile of epitopes expressed by the parental B16-F10 tumours, leading to significant numbers of tumour cures (Fig. 3C). Those B16-F10-specific heteroclitic responses existed amongst a larger population of CD8+ T cells which also recognized B16-F10-(AIRE)-specific targets (Fig. 3D).