Interestingly, we found that the CAD GWAS variant rs4887091 (located within enhancer element chr15:78750919–78751419) was part of a super chromatin interactome that consisted of numerous genes such as CHRNA3, CHRNA4, MORF4L1, CHRNA5, CTHS, and ADAMTS7 which were also V2E2G for rs4887091 – notably, CHRNA3, CHRNA4, and ADAMTS7 were also arterial eQTLs for rs4887091 (Fig. 5e,f). This evidence concerns the gene CHRNA4 and coronary artery disorder.