We screened genetic variants in key genes linked to these conditions, including APP, PSEN1, PSEN2, TREM2, MAPT, GRN, GBA, SNCA, and APOE across a total of 25,001 AD/ADRD cases and 93,542 control individuals, collectively representing 11 ancestries. The gene discussed is PSEN2; the disease is Alzheimer disease.