OCA2 and albinism: The gene responsible for albinism is oculocutaneous albinism 2 (oca2), which was identified initially through QTL mapping, and confirmed through functional studies, including generation of surface fish with mutations in this gene and finding that the resulting animals lacked melanin pigmentation (Protas et al., 2006; Ma et al., 2015; Klaassen et al., 2018).