Individual TLRs or NOD are transfected into a human embryonic kidney (HEK) cell line, or the THP-1 monocytic leukemia cell line for STING agonist analysis, in conjunction with an NF-κB (TLR, NOD) or interferon regulatory factor (IRF) (STING) reporter gene readout. The gene discussed is TRIM63; the disease is leukemia.