PBRM1 and Crohn disease: The chromatin remodeler polybromo-1 (PBRM1) belongs to the SWI/SNF family, and some patients with Crohn’s disease and ulcerative colitis (UC) have been found to have low levels of PBRM1 expression, which leads to an increase in the expression of IFN and several proinflammatory cytokines through the activation of the retinoic acid-inducible gene-I-like receptor (RLRs) signaling pathway, thus exacerbating inflammation in patients (141).