AIRE and autoimmune polyendocrine syndrome type 1: Mutations in the AIRE gene impede the expression of the tissue-specific antigen by medullary thymic epithelial cells (mTECs), resulting in the compromised clearance of autoreactive T-cells or induction of Treg production, which in turn triggers a severe multiorgan damaging autoimmune disease, namely autoimmune polyendocrine syndrome type 1 (APS-1) (67).