In addition, interferon-induced protein 44-like (IFI44L), an interferon-regulated gene that can amplify IFN signaling and enhance the immune response is hypomethylated in CD4+ T-cells from patients with SLE; thus, the DNA methylation of the IFI44L promoter can serve as a potential blood biomarker for diagnosing SLE with high sensitivity and specificity (180). The gene discussed is CD4; the disease is systemic lupus erythematosus.