Following the pharmacological inhibition of METTL3 in lupus model mice, the m6A modification on the transcription factor Foxp3 mRNA was reduced, in turn facilitating RNA degradation, and resulting in impaired differentiation and immunosuppressive function of Treg cells as FOXP3 is indispensable for the development and function of Treg cells, thus exacerbating kidney injury in mice (204). Here, FOXP3 is linked to systemic lupus erythematosus.