For instance, in gastric cancer, IGF2BP1 overexpression augments the proliferation of co-cultured gastric cancer cells, and mitigates the CD8+ T cells mediated anti-tumor response, including IFN-γ secretion, surface PD-L1 level, and cytotoxicity of CD8+ T cells (23). The gene discussed is IGF2BP1; the disease is gastric cancer.