CD274 and hepatocellular carcinoma: Firstly, the expression of PD-L1 on the surface of HCC cells (MHCC97H) was measured, revealing that overexpression of c-Myc enhanced the expression of PD-L1 on the cellular surface of HCC cells, whereas IGF2BP1 silencing and PD-L1 silencing both reduced the PD-L1 surface expression (Figure 6A).