CD4 and cancer: Patient cluster 2 (“hot” tumors): associated to intermediate presence of cancer cells, several CAF signatures, some myeloid cells (M1 macrophages and monocytes), some lymphocytes (CD4 T helper) and some type of unspecified NK cells and low abundance of naive B cells, resting CD4 and dendritic cells and NK cells denoted as activated with varying levels of a group of non-naive B cells.