Several chemokines within the CXCL family, such as CXCL1, CXCL2, CXCL5, CXCL8 (IL-8), and CXCL12, also play a crucial role in the recruitment of myeloid cells and TAM in bladder cancer, and are associated with tumor grading, staging, and metastasis (2). The gene discussed is CXCL2; the disease is urinary bladder carcinoma.