Simultaneously, TAMs secret a variety of chemokines such as CCL2, CCL5 and CCL22, recruiting Th2 cells, Treg cells, bone marrow-derived suppressor cells (MDSC), and macrophages themselves to the tumor site, which amplifies the immunosuppressive Th2 immune response and promotes the differentiation of additional macrophages into the immunosuppressive TAM phenotype. This evidence concerns the gene CCL2 and neoplasm.