CCR2 and urinary bladder carcinoma: For example, the expression of CCL2 is regulated by lncRNA LNMAT1 in bladder cancer (37), which recruits TAM and induces the polarization of M2-TAMs via the CCL2-CCR2 axis, while also stimulates its autocrine circulation, and up-regulates the secretion of VEGF-C thereby fostering lymphogenesis and lymphatic metastasis, which is significantly correlated with the grade and stage of bladder cancer (61).