Several chemokines within the CXCL family, such as CXCL1, CXCL2, CXCL5, CXCL8 (IL-8), and CXCL12, also play a crucial role in the recruitment of myeloid cells and TAM in bladder cancer, and are associated with tumor grading, staging, and metastasis (2). This evidence concerns the gene CXCL12 and neoplasm.