These SIRPα+ TAMs recognize CD47 on tumor cells, thereby activating the “don’t eat me” signaling pathway and counterbalance the pro-phagocytic signal calreticulin (55), leading to the inhibition of macrophage-mediated phagocytosis of tumors and is strongly associated with immune escape through T cell depletion (56, 57). This evidence concerns the gene SIRPA and neoplasm.