However, using EGFRvIII to trigger expression of a tandem CAR targeting two glioma-associated antigens, EphA2 and IL13Ra2, that are more uniformly expressed on GBM though are also found on some healthy tissues, creates a construct that significantly restricts the tumor’s ability to escape while limiting on-target/off-tumor toxicity (110). Here, IL13RA2 is linked to glioblastoma.