TMOD1 and neoplasm: Use of both mixed and serial cultures showed that the Tmod constructs could not only distinguish between tumor and normal cells (defined as both cells being CAR TAA-positive, with the tumor cells being HLA A*02-negative and the normal cells being HLA A*02-positive) in a mixed culture, but also showing that the kinetics of the Tmod system were fast enough to enable the Tmod blocker to inhibit CAR-T cell activation when the Tmod cells were transferred from a tumor to a normal cell culture, with no cytotoxicity being observed in the normal cells.