HLA DR+ CD4+AC [IVW: odds ratio (OR) 1.0341, 95% confidence interval (CI) 1.0089–1.0599; p = 0.0076], CD45 on CD8br [IVW: odds ratio (OR) 1.0137, 95% confidence interval (CI) 1.0046–1.0231; p = 0.0033], and HLA DR on plasmacytoid DC [IVW: odds ratio (OR) 1.0424, 95% confidence interval (CI) 1.0128–1.0729; p = 0.0047] were risk against urticaria. The gene discussed is CD4; the disease is urticaria.