Furthermore, reduced phosphorylation of the subunit p47-phox of the NADPH oxidase complex, an intrinsic enzyme of the reactive oxygen species (ROS) cascade, in iMacΔF508 compared to iMacWT 30min post infection points towards an impaired or defective ability of diseased iMacs to efficiently produce ROS (Supplementary Figures 2A, B). The gene discussed is FMO5; the disease is infection.