Interestingly, previous studies identified that in a cohort of patient’s carriers of Hereditary Angioedema (HAE), presenting both type I or II phenotypes of the disease, a fall in the levels of MASP1-C1INH complexes, which was correlated with several aspects of the disease, including, C4 consumption and the number of attacks through the year of blood samples drawing (75). Here, MASP1 is linked to hereditary angioedema.