Interestingly, previous studies identified that in a cohort of patient’s carriers of Hereditary Angioedema (HAE), presenting both type I or II phenotypes of the disease, a fall in the levels of MASP1-C1INH complexes, which was correlated with several aspects of the disease, including, C4 consumption and the number of attacks through the year of blood samples drawing (75). This evidence concerns the gene SERPING1 and hereditary angioedema.