In bilateral mouse tumor models, HFRT treatment of the primary tumor combined with LDRT treatment of the abscopal tumor and anti-PD1 therapy enhances the response compared with HFRT/anti-PD1, HFRT/LDRT, or LDRT/anti-PD1 treatments and complete response was observed in more than half of the mice treated with triple therapy. Here, PDCD1 is linked to neoplasm.