REN and obstructive sleep apnea syndrome: Indeed, plasma renin activity wassignificantly higher (P = .0025) in participants with OSAsymptoms in our cohort (Fig. 2A).Plasma renin activity was significantly higher in the rs2254298 A genotype(P = .011, recessive model) than in the G genotype,supporting OSA symptom exacerbation in the A genotype (Fig. 2B).