Since rhabdomyosarcoma and peripheral malignant nerve sheath tumors, etc, can also abnormally express MDM2 and CDK4, and the sensitivity of p16 expression in DDLPS is 98%, combined detection of MDM2, CDK4, and p16 genes is often recommended to avoid misdiagnosis (44). This evidence concerns the gene CDK4 and malignant peripheral nerve sheath tumor.