For instance, H2O2 reduces SOCE current in prostate cancer cell lines (Holzmann et al., 2015) and human platelets (Redondo et al., 2004), and increases mRNA expression of Orai1 and Stim1 in bovine brain capillary endothelial cells (Yamamura et al., 2020). This evidence concerns the gene ORAI1 and Familial prostate cancer.