Although the role of HIF-1 in cancer is well-known, there remains a lack of comprehensive investigation into its connections with important variables such as VEGF, GLUT-1, and OGT within the framework of epigenetic mechanisms, along with other crucial entities such Extracellular single regulated kinase (ERK), β-catenin, p53, AKT, and C-MYC. This evidence concerns the gene TP53 and cancer.