The complex relationships between HIF-1, O-glycosylation transferase (OGT), Vascular endothelial growth factor (VEGF), and protein kinase B (AKT) are crucial because they all work together to control the expression of several enzymes involved in glucose and fatty acid metabolism as well as the regulation of glucose transporters during the start and development of cancer (Panieri and Santoro, 2016). This evidence concerns the gene HIF1A and cancer.