In the upregulated group, significantly enriched pathways included systemic lupus erythematosus, arginine biosynthesis, Vibrio cholerae infection, nitrogen metabolism, rheumatoid arthritis, intestinal IgA production immune network, collecting duct acid secretion, Staphylococcus aureus infection, and asthma, among others (Figure 1D). This evidence concerns the gene CD79A and rheumatoid arthritis.