TP53 and cancer: The structure‒function analysis of FBL showed that both major structural domains of FBL are capable of functioning in the cell (Figure 7), and we further generalized its role in cellular homeostasis, reproduction, inflammation and autoimmunity, and provided a detailed description of the pattern of FBL-mediated chemical modification of rRNAs (partly through p53-mediated modulation of the ribosome biosynthetic machinery) in cancer cells, opening up the possibility of developing anticancer molecules that target these “cancer ribosomes”.