Macrophage-derived lncRNA Livr-AS1 (Zhang et al., 2021), miRNA-221–3p (Liu et al., 2021b), let-7a (Yan et al., 2023); lncRNA OIP5-AS1 (Li et al., 2021a) CTCF (Zhan et al., 2022) derived from osteosarcoma cells can all participate in the progression of osteosarcoma, as shown in Figure 6. This evidence concerns the gene OIP5 and osteosarcoma.